ANTIBODY-MEDIATED DELIVERY OF A VIRAL MHC-I EPITOPE INTO THE CYTOSOL OF TARGET TUMOR CELLS REPURPOSES VIRUS-SPECIFIC CD8+ T CELLS FOR CANCER IMMUNOTHERAPY

Abstract Background Redirecting pre-existing virus-specific cytotoxic CD8+ T lymphocytes (CTLs) to tumors by simulating a viral infection of the tumor cells has great potential for cancer immunotherapy.However, this strategy is limited by lack of amenable method for viral antigen delivery into the cytosol of target tumors.Here, we addressed the lim

Ectomycorrhizal (ECM) fungal propagule bank could facilitate the regeneration and plantation of seedlings in disturbed area.In this study, Masson pine (Pinus massoniana) seedlings were used to bait the ECM fungal propagule bank buried in the soils collected from a manganese (Mn) mine wasteland and a non-polluted area in China.After 6-month growth,

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) represents the most common type of CP, characterized by complex pathogenesis and a wide array of symptoms, making diagnosis and treatment OATMEAL CHOCOLATE CHIP challenging.Acupuncture, a widely used treatment for chronic and painful conditions, has demonstrated clinical efficacy in restori

Model-based verification allows to express behavioral correctness conditions like the validity of execution states, boundaries of variables or timing at a high level of abstraction and affirm that they are satisfied by SAGE LEAF a software system.However, this requires expressive models which are difficult and cumbersome to create and maintain by h

Customer relationship management (CRM) has a growing popularity and is becoming one of the hottest academic SAGE LEAF and practical topics in the business field.In fact, due to the competitive environment, CRM is crucial and has become a niche for firm performance.However, there is limited research that reveals the relationship between CRM dimensio